However, we accept that illegal drug use occurs, and believe that offering responsible harm reduction information is imperative to keeping … In a phase I/II study with breast cancer patients, maitake liquid extract has been given orally at 0.1- 5 mg/kg twice daily 11. The activity of Natural Killer cells, cytotoxic T-cells and delayed-hypersensitive T-cells were all increased by 1.5-2.2 times by Maitake D-fraction. But the good news is that a 2013 study found that a daily dose of Maitake lowered cholesterol levels in mice. Though the data is preliminary, the results of animal (and limited clinical ) studies based on Maitake D-fraction suggest significant healing and preventing potential for cancers and other immune-related health disorders. In the U.S. it is currently being studied in medical clinics in the U.S. for patients with breast and colorectal cancers (Miller, 1994). Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others. The appropriate dose of maitake mushroom depends on several factors such as the user's age, health, and several other conditions. Turkey Tail mushrooms can be kept for years without losing any of their medicinal potency. (For more information, see the Mushroom Poisoning Decision Chart monograph). Since no abnormality was found in this test, we came to the conclusion that there is no toxicity in the D-fraction. Maitake (Grifola frondosa) is a delectable mushroom that is extremely popular in Japan. Why is Maitake Beneficial for Improving Pet Immunity? Maitake May Suppress Cancer. turmeric, Ginkgo Biloba, saw palmetto, garlic. The purified D-fraction extract and Maitake crude tablets were tested using mice to investigate acute and chronic toxicity. In vitro studies indicate maitake beta-glucan had a suppressive, but not cytotoxic, effect on hematopoiesis at 200 mcg/mL, while maitake-derived grifon-D extract was cytotoxic to human prostate cells at doses of 480 mcg/mL or more.28. This product may be unsafe when used before surgery or other medical procedures. The following are some of the typical cases which demonstrated improvements by taking Maitake D-fraction and tablets. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Studies have shown cancer fighting mushrooms exist due to anti-tumor and anti-inflammatory properties by induction of apoptosis accompanying modulated cell cycle progression. Nonresponders in either monotherapy group were subsequently given Maitake plus clomiphene combination therapy. If you decide to take it as a supplement, look for maitake D-Fraction, which is an extract of the mushroom. Most other mushroom extracts are reported ineffective when given orally.4,5 The results of human studies on Maitake D-fraction is reported which indicated strong potential of Maitake D-fraction for cancer treatment. Furthermore, 5 mg/kg of D-fraction was injected for 120 days and the toxicity was investigated in the same manner. The result indicates some synergistic effect between MMC and Maitake, i.e., tumor cells are directly attacked by MMC while the immune system is activated by D-fraction. Chemotherapy is supposed to kill cancer cells directly. However, we did the same test as was done with the D-fraction, by feeding it to mice by mixing it in their diet at a 1:4 ratio for a period of 13 months. I have been studying medicinal mushrooms for the last 15 years and have reported that of all mushrooms studied, Maitake Mushroom (Grifola frondosa) has the strongest activity in tumor growth inhibition both in administered orally and intraperi-toneally.1,2,3. Usual dose: About 3 to 5 grams per day. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age. This Magic Mushroom Dosage Guide will help you prepare the trip you are looking for!. Mice in experiment groups were administered either 0.5 mg/Kg of D-fraction by I.P. It can not be concluded that Maitake D-fraction and crude powder alone have the strong anti-cancer activities in human cancer. Consuming Turkey Tail mushrooms can benefit anybody, even those in good health. Reduction of the pain was also reported by 83% of the patients. I have been studying medicinal mushrooms for the last 15 years and have reported that of all mushrooms studied, Maitake Mushroom (Grifola frondosa) has the strongest activity in tumor growth inhibition both in administered orally and intraperi-toneally.1,2,3 In this report, Maitake extract D-fraction was investigated to determine its effectiveness not only on the inhibition against tumors already growing, but also on the inhibition of formation … May be consumed as capsules, tablets, liquid extract, or raw mushrooms. Maitake D-fraction or PDF is the bioactive extract of maitake mushroom (Grifola frondosa) and its active constituent is the protein-bound polysaccharide (proteoglucan), or more specifically known as β-glucan.PDF has been extensively studied and a number of its medicinal potentials/properties have been unveiled and demonstrated. This information relates to an herbal, vitamin, mineral or other dietary supplement. Stay Healthy! According to the study, maitake induced tumor growth by 86% compared to untreated animals. S. F. Gray.Common Name(s): Dancing mushroom, Hen of the woods, Huishu hua, King of mushrooms, Maitake, Monkey's bench, Ram’s head, Sheep’s head, Shelf fungus. 71 years old, male, Lung cancer (epidermoid carcinoma) He was diagnosed as advanced stage IV but refused to take chemotherapy. She received trans-catheter arterial embolization (TAE) in January, 1994, and 10 mil of lipiodol, 15 mg of ADM and 100 mg of Cisplatin (CDDP) were administered by injection. Which is more effective in terms of cancer growth inhibition? To compare, one banana contains approximately 422 mg of potassium compared to 10 times that amount in the same measurement of maitake. These mushrooms have not been studied thoroughly in people, so the side effects are not well known. 3) if T, N or M factors reduced or remained unchanged. As a result, scientists are now proposing that Maitake may have similar benefits in humans – although, as with much of the mushroom research out there, more work needs to be done. However, dosage can vary due to factors such as height, weight, sex, and potency of the supplement. Maitake mushroom does not kill cancer cells directly. There are a limited number of well-designed clinical trials investigating maitake's effects in cancer therapy. People who found the mushroom in deep mountain valleys started dancing with joy since they knew its delicious taste and the health benefits. However, she gave up taking these chemos in March, 1994, because of severe side effects. Beta 1,6-glucan, a protein bound polysaccharide, has been identified as the active constituent. Its extracts are commercially available as dietary supplements marketed to “enhance immune function” and to treat HIV and cancer. 53 years old, female, Lung cancer (epidermoid carcinoma) In November, 1993, she was diagnosed as stage III-A according to the TNM classification by UICC (Unia Intern Contra Cancrum). Additional controlled studies are needed. Various side effects from chemotherapy such as lost appetite, vomiting, nausea, hair loss and leukopenia (deficiency of white blood cells) were ameliorated by 90% of the patients. Among the various fractions in the process of standardization of the mushroom extraction, it is known that Maitake D-fraction is most potent in enhancing the immune system, demonstrating highest cancer inhibition in oral administration.3,6 The protein-bound Maitake D-fraction is the acid-insoluble, alkali-soluble and hot water extractable fraction (1,6 beta-glucans carrying 1,3 branched chains) with molecular weight of about one million. You should talk with your health care provider for complete information about the risks and benefits of using this product. He took 35 mg of D-fraction and 4 g of Maitake caplet per day. Capsules or tablets available in stores or via the internet usually contain 200-400mg of extracts from mycelium cultures or 400-500mg pulverized fruiting bodies or spora. T-factor 3 means that tumor diameter is more than 2 cm and some tumors remove into blood vessels. Commercial preparations commonly provide 3 to 25 mg of standardized D – or MD-fraction plus 75 to 250 mg whole powder per capsule. These mushrooms also contain a healthy dose of vitamins B and C, copper, potassium, beta-glucans, and amino acids. Then, 200 mg of 5-FU was orally administered for 60 consecutive days but no improvements were observed. This has been declared by the scientists after research on mice found closure. Are there any risks? Patients were either taking Maitake D-fraction with crude powder tablets only, or Maitake D-fraction, crude tablets in addition to chemotherapy. This information should not be used to decide whether or not to take this product. If you are finding our posts helpful and informative why not sign up to our newsletter. What is the history behind it? The appropriate dose of maitake mushroom depends on several factors such as the user's age, health, and several other conditions. But for people who dislike the taste or texture, it can be taken in its dried form in capsules. In the late 1980s, Japanese scientists identified the maitake as more potent than lentinan, shiitake, suehirotake, and kawaratake mushrooms, all of which are used in traditional Asian medicine for immune function enhancement.1. The effect of maitake on CD4+ count and viral load was minimal.6, An in vitro experiment demonstrated that lysophosphatidylethanolamine, a chemical component of maitake, evoked a cascade mechanism that resulted in the induction of neuronal differentiation and the halting of neuronal apoptosis.17. Immunostimulant activity is a characteristic of many medicinal mushrooms, including shiitake, suchirotake, or kawaratake, that are used clinically as anticancer drugs in Japan.1 Maitake's polysaccharide may be slightly different from the beta-glucans found in other fungi. He had taken D-fraction 70 mg and 6 g tablets everyday but unfortunately died 20 months later. These results highlight the relativity of an "optimal dose," which is dependent on the specific immunological parameter measured.49, In a study of 165 patients, results suggested that quality of life indicators had improved. Educating ourselves… You'll receive medicinal mushroom articles and product updates and exclusive member discounts at the store. Clinical case studies of liver, lung, stomach, breast, brain, and prostate cancers involving the use of maitake have been reported.1 A phase 1/2 dose-escalation trial in 34 postmenopausal (natural or treatment-induced) breast cancer patients who were currently disease-free, reported the largest functional immunological increases (more than 50% above baseline) in granulocyte response as well as production of interleukin (IL)-10, IL-2, and tumor necrosis factor-alpha by various subsets of T cells. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. Based on a previous animal test which indicates the optimal dose of 1mg/kg of D-fraction for anti-tumor activity, ten times more dosage was employed intraperit-oneally for 30 days. It is important to note that even among Maitake Mushrooms ( Grifola-frondosa), there are many strains and some contain very little Beta-glucan, the active ingredient to stimulate the immune system. A non-randomized clinical study using D-fraction was conducted to see if it is effective against advanced cancer patients as it is against animals. A total of 165 cancer patients in stage III-IV, from 25-65 years old, participated in the study and the data was collected under the cooperation of their medical doctors with major university hospitals and cancer treatment clinics in the western part of Japan. Breast cancer… These cells were treated with maitake (D fraction) extract at 18 μg/mL, 36 μg/mL, 91 μg/mL, 183 μg/mL, or 367 μg/mL or were left untreated (control) for 24 hours. Maitake has been studied to a limited extent for treating cancer; however, the information available is not sufficient to recommend it for this use. Disclaimer: Psilocybin mushrooms are potentially illegal substances, and we do not encourage or condone the use of this substance where it is against the law. Tags: Hen of the woods, maitake extract, maitake herb, maitake study, organic maitake, ​Use The Below Code Now To Save 15% On Your First Order. Maitake mushroom contains: Beta-glucans; Vitamins B, C, and D; … 7 Surprising Health Benefits of Maitake Mushroom The Ability to Fight Cancer. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. The basket-ball sized mushroom, weighing sometimes over 50 pounds, grows on the foot of old Japanese oak trees. Many years ago in Japan, the maitake actually had monetary value and was worth its weight in silver. We comply with the HONcode standard for trustworthy health information -. In this context, various tests were conducted focusing on inhibition of growth and metastasis of cancer after surgery, by oral administration of Maitake. All three groups were bred for another 30 days, and the number of tumor focus metastasized in the liver was counted by microscope. I recommend at least 300mg of mushrooms be given daily for every 50lb of cat or dog. This legendary giant mushroom has been available by cultivation since the mid 1980s which gave opportunities for mycologists and pharmacologists to study the various medicinal properties on the mushroom as claimed in anecdotes and folklore. of tumor focus and had the rigid pleura. After 4 months since he started taking Maitake, a complete regression of an egg-sized tumor focus was confirmed. In contrast, about a 20% decrease was noted in interferon-gamma production at a high dose (10 mg/kg/day). M-factor1 means that there is remote metastasis. Eating freshly cooked maitake mushrooms will provide you with the most health benefits. As of July, 1995, value of bilirubin was 2.7, albumin 3.1, and prothrombia activation was improved to 63%. Information regarding safety and efficacy during pregnancy and lactation is lacking. A positive response is defined as one of the following: We use cookies to ensure that we give you the best experience on our website. In this report, Maitake extract D-fraction was investigated to determine its effectiveness not only on the inhibition against tumors already growing, but also on the inhibition of formation of the secondary focus due to metastasis of tumor cells in lymph and/or blood. Anecdotes and folklore on its medicinal values have also been elucidated by a number of mycologists and pharmacologists and its strong anti-tumor activity has attracted many researchers. Top 5 Benefits of Eating Maitake Mushrooms Slows Down Breast Cancer - Studies conducted by Memorial Sloan-Kettering Cancer Center have shown that consumption of maitake mushrooms helps in stimulating the immune systems of breast cancer patients. The patient has taken 100 mg of D-fraction and 6 g of Maitake tablets every day for 4 months without taking any other medication including chemotherapy or radiation. The evidence suggests that its greatest benefit is found when used in conjunction with evidence-based conventional treatment. Store them away from heat and light to extend their shelf live even further. From such strains of Maitake mushroom, D-fraction may not be obtained. Another interesting of investigation was whether the formation of secondary focus due to metastasis of cancer cells could be inhibited. After 6 months, the dose of D-fraction reduced to 50 mg a day. Structural characterization of maitake extract constituents18 and carbon-13 nuclear magnetic resonance analysis of the fruit body's constituents19 have been conducted. In this case, the patient showed dramatic improvement. In China a maitake extract was shown to have an anticancer effect in patients with lung, s… What does the research show? Maitake contain: 377 calories per 100 grams dry weight; 25 percent protein As can be seen, these results suggest that breast, lung and liver cancers were improved by Maitake, but it was less effective against bone and stomach cancers or leukemia. Whole powder capsules generally contain 100 to 500 mg, and a liquid extract of 1 mg D-fraction extract per drop is available. In addition to its antitumor effect, anti-hypertension, anti-diabetes, anti-obesity and anti-hepatitis activities have been found in Maitake. Available for Android and iOS devices. The result was that Maitake outperformed all other mushrooms. Medically reviewed by Drugs.com. The best approach with mushrooms is to use the ones best suited for your targeted weaknesses and genetic susceptibilities. Here are the correct Heroic dose & Microdosing amounts. Maitake mushrooms are a seriously healthy food, they have an abundance of b-vitamins and a shocking amount of potassium. Of these patients, 90% reported an improvement in cancer-treatment symptoms (eg, nausea, hair loss) and 83% reported pain reduction.38, When maitake powdered fruit body was administered orally to genetically diabetic mice, blood glucose reduction was observed compared with a control group.39 Maitake may control blood glucose levels by possible reduction of insulin resistance and enhancement of insulin sensitivity.1, Insulin resistance and hyperinsulinemia are prominent features of polycystic ovary syndrome (PCOS). 51 years old, male, Liver cancer (hepatocellular carcinoma) He had received Adriamycin (ADM) since 1993, but refused it because of little effectiveness and severe side effects of chemotherapy. In this animal test, Maitake D-fraction, MMC , and D-fraction and MMC together (cutting each dose by half) were injected into tumor-bearing mice respectively. In a human trial, conducted by Memorial Sloan–Kettering Cancer Centre in 2009 , maitake was shown to … A trial among HIV patients used daily doses of 6 g whole powder per day or 20 mg purified extract with 4 g whole maitake powder.6, However, there are limited clinical studies to substantiate the efficacy or safety of this dose.1. CDDP 80 mg/m, CPA 350 mg/m and ADM 50 mg/m were administered. According to the research, maitake mushrooms contain D-fraction, a polysaccharide benefitting human patients with bladder cancer, renal cell carcinoma, and breast cancer among others. The polysaccharide beta-glucan is present in low quantities (0% to 0.2%)2 in most of the mushrooms in the Polyporaceae family (eg, reishi mushroom) and possesses antitumor activity.1 The D fraction of beta-glucan appears to be the most active and potent form of the polysaccharide, a protein-bound extract developed in Japan.5 An MD-fraction has now been described, as well, with purportedly superior activity.1, 6 Both structure-functional relationship7 and fractionation by anion exchange chromatography of beta-glucan8 have been reported. Maitake D-fraction has strong ability to potentiate and activate the cellular immune system. The criteria to judge the effectiveness are established as follows. She is now diagnosed as stage I. Additionally, maitake contains polysaccharides and b-1,6-glucan, which have anti-tumor effects. A combination can be used or focus on one. Even though this was a limited and non-controlled trial, the clinical study indicated that Maitake D-fraction is effective against such cancers of the breast, lung, liver, prostate and brain. Maitake mushrooms are believed to have similar qualities. ex Fries).3, 4 The maitake mushroom grows in clusters near the foot of oak trees and can reach 50 cm in base diameter. Maitake mushrooms are best known for their cancer-fighting properties, which were researched in 2009 during a study by Memorial Sloan-Kettering Cancer Center. It is commonly known as Hen of the Woods, Ram’s Head and Sheep’s Head, and its Japanese name, maitake… ​Thanks for signing up :)  We hope you find our articles helpful and enjoyable! 45 years old, female, Breast cancer (intraductal carcinoma) ER+ (Estrogen receptor positive) was observed on this patient who had 1.8 cm dia. Maitake extracts exhibited … A randomized, open-label comparator trial (n = 57) investigated the ability of monotherapy and combination therapy of a maitake extract formulation (standardized to at least 18% SX-fraction) and clomiphene citrate to induce ovulation in women with PCOS. Among the various fractions in the process of standardization of the mushroom extraction, it is known that Maitake D-fraction is most potent in enhancing the immune system, demonstrating highest cancer inhibition in oral administration. Maitake (Pron. In December, 1994, she started taking 55 mg of D-fraction liquid and 6 g of Maitake tablets everyday. What Are Adaptogens And How can They Help Your Body Function During Stressful Times. Maitake (grifola frondosa) is a polypore mushroom that is native to Japan. Maitake (Grifola frondosa) is an edible mushroom known in the United States as “hen of the woods” because it resembles the fluffed tail feathers of a nesting hen. This information is not specific medical advice and does not replace information you receive from your health care provider. Amazing cancer cure case studies with maitake mushroom has been clinically proven to prevent and heal cancer, as well as decrease and even eliminate cancerous tumors. “my-tah-key”) is indigenous to northern part of Japan. At this time there is not enough scientific information to determine an appropriate range of doses for maitake mushroom. The best mushrooms to use for an animal with cancer are maitake, shiitake, reishi and cordyceps. Disease-prevention doses of commercial preparations range from 12 to 25 mg of the extract and 200 to 250 mg or 500 to 2,500 mg of whole powder daily. Maitake has been appreciated by the Japanese people as the premier culinary mushroom for hundreds of years, and it is therefore unlikely to exhibit any toxicity. Maitake for the win! Maitake Uses, Benefits & Dosage - Drugs.com Herbal Database As of may, 1995, it was confirmed that the recurred tumor focus disappeared. A number of animal tests have confirmed Maitake’s strong ability in cancer inhibition.7-10 but human trials have not been conducted until recently. He hopes his passion will rub off on you in a positive way. The remaining six rodents also indicated almost 90% suppression rate compared to untreated (control) mice. After 8 months, the level of bilirubin and albumin are improved as well as T and N factors. N-factor 1 means that the tumors metastasized to lymph nodes. 2) if the value of tumor mark decreased. After 18 weeks, overweight rats fed unheated maitake powder lost weight compared with controls.46 In an observational study, 30 patients lost between 3 and 12 kg (7 and 26 lbs) after administration of 20 to 500 mg tableted maitake powder per day for 2 months.47, In an in vitro study, the D-fraction of maitake exhibited an inhibitory action on the hepatitis B virus alone and a synergistic action with interferon alpha-2b.48, A human trial of poor methodology attempted to demonstrate a positive effect on CD4+ count and viral load. We know that tumors are of two types- benign and malignant. Now go spend your 15% OFF voucher. 44 years old male, Brain tumor (astrocytoma) This is an example of an effective trial of D-fraction therapy against a brain tumor. It is devastating news and leaves you thinking what could you have done differently to of prevented this from happening. This, in turn, slows down the growth of tumor cells (link) (link). injection for 10 days or 1.0 mg/Kg of D-fraction by oral administration for 10 days. In addition to its anti-cancer, anti-viral and immune-enhancing properties, maitake may also reduce blood pressure and blood sugar. Maitake has a rippling, flowery appearance resembling dancing butterflies, hence one of its common names, dancing mushroom.1, In China and Japan, maitake mushrooms have been consumed for 3,000 years, valued most for their legendary properties. Also, it was observed that production of interleukin-1 (which activates T cells), and super-oxide anion ( which damages tumor cells) were enhanced. N-factor 2 means that tumor metastasized to lymph nodes (homolaceral mediaspinum). The result of this animal test indicates that cancer metastases could be reduced to less than one tenth by the use of Maitake D-fraction daily. He had received chemotherapy (CCNU) in four cycles since February, 1994. A mean decrease in diastolic blood pressure of approximately 8 mm Hg and a mean decrease in systolic blood pressure of about 14 mm Hg were reported.43, Maitake altered lipid metabolism by inhibiting the accumulation of liver lipids and the elevation of serum lipids in hyperlipidemic rats.44 Similar results were seen in rats fed a high-cholesterol diet.45 In another report, total cholesterol and very low density lipoprotein-cholesterol decreased in rats given powdered mushroom preparations.40, At least 2 studies are available concerning maitake's antiobesity activity. Although ovulation cycle rates were significantly higher with clomiphene monotherapy than maitake extract (69.9% vs 41.7%, respectively), 87% of monotherapy nonresponders ovulated with the combination therapy.50. This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. At present, it is not permitted to inject D-fraction into the human body, therefore, in our study the D-fraction was used via oral administration. It should be noted that, unlike many other mushroom extracts that have to be injected intravenously, Maitake D-fraction has a strong ability to inhibit tumor growth when given orally as well. Maitake is often said to boost immune function and, in turn, fight certain infections.Maitake mushroom is used to treat cancer and also to relieve some of the side effects of chemical treatment (chemotherapy) for cancer. Meanwhile, T-factor improved from 3-4 to 1-2 and N-factor changed from 0-1 to 0. 4) if the remaining life expectancy indicated by the doctor was prolonged by more than 4 times. Maitake literally means “Dancing Mushroom”. Maitake tablets were also investigated for possible toxicity. Maitake was, and still is, one of the most valuable and expensive mushrooms. It was observed that the metastasis to the liver was prevented by 91.3% by the administration of D-fraction and by 81.3% by Maitake powder. However, he showed improvement and was diagnosed as stage III-A before he died. Keep in mind that natural products are not always necessarily safe and dosages can be important. Maitake are known to help stimulate the immune system. T-factor 2 means that tumor size is more than 3 cm and tumors advanced to the hilus. Maitake fruiting body extract, standardized to contain 30% D-fraction - 240mg (so 72mg D-fraction beta glucan) Vitamin C 120mg (supports bioactivity) Cost-permitting, in most clinical studies, the daily dose of mushroom extracts that is correlated with improved survival (especially in breast, colorectal, gastric cancers) is 3000mg/day. Before you read this article I recommend that you read another article we have written that shows the top 10 types of psilocybin mushrooms and their different potency levels.
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